Unconjugated - Gilbert's (diminished glucuronyl transferase);
Crigler-Najjar (glucuronyl transferase deficiency); Physiologic newborn
(immature glucuronyl transferase)
Conjugated - Obstruction, Rotor's (inadequate storage); Dubin-Johnson (poor secretion)
QUESTION: In a patient with elevated direct hyperbilirubinemia due to obstruction, why would INR be elevated?
ANSWER:
Bile helps absorb fat and Vitamin K is a fat soluble vitamin that is
needed for the extrinsic clotting factor coagulation
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